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分子腫瘍学分野

研究業績

【原著論文】

    (2019)
  1. Matsushita A, Sato T, Mukai S, Fujishita T, Mishiro-Sato E, Okuda M, Aoki M, Hasegawa Y, Sekido Y. TAZ activation by Hippo pathway dysregulation induces cytokine gene expression and promotes mesothelial cell transformation. Oncogene 38:1966-1978, 2019. (PMID: 30401981)
    (2018)
  1. McCambridge AJ, Napolitano A, Mansfield AS, Fennell DA, Sekido Y, Nowak AK, Reungwetwattana T, Mao W, Pass HI, Carbone M, Yang H, Peikert T: State of the Art: Advances in Malignant Pleural Mesothelioma in 2017. J Thorac Oncol. pii: S1556-0864(18)30175-8, 2018. (PMID: 29524617)
  2. Sekido Y: Targeting the Hippo Pathway Is a New Potential Therapeutic Modality for Malignant Mesothelioma. Cancers (Basel). 10(4). pii: E90, 2018. (PMID: 29565815)
  3. Sato T, Sekido Y: NF2/Merlin Inactivation and Potential Therapeutic Targets in Mesothelioma. Int J Mol Sci. 19(4). pii: E988, 2018. (PMID: 29587439)
  4. Tanaka I, Sato M, Kato T, Goto D, Kakumu T, Miyazawa A, Yogo N, Hase T, Morise M, Sekido Y, Girard L, Minna JD, Byers LA, Heymach JV, Coombes KR, Kondo M, Hasegawa Y. eIF2β, a subunit of translation-initiation factor EIF2, is a potential therapeutic target for non-small cell lung cancer. Cancer Sci. 109:1843-1852, 2018. (PMID: 29624814)
  5. Hmeljak J, Sanchez-Vega F, Hoadley KA, Shih J, Stewart C, Heiman DI, Tarpey P, Danilova L, Drill E, Gibb EA, Bowlby R, Kanchi R, Osmanbeyoglu HU, Sekido Y, Takeshita J, Newton Y, Graim K, Gupta M, Gay CM, Diao L, Gibbs DL, Thorsson V, Iype L, Kantheti HS, Severson DT, Ravegnini G, Desmeules P, Jungbluth AA, Travis WD, Dacic S, Chirieac LR, Galateau-Salle F, Fujimoto J, Husain AN, Silveira HC, Rusch VW, Rintoul RC, Pass H, Kindler H, Zauderer MG, Kwiatkowski DJ, Bueno R, Tsao AS, Creaney J, Lichtenberg T, Leraas K, Bowen J, Research Network T, Felau I, Zenklusen JC, Akbani R, Cherniack AD, Byers LA, Noble MS, Fletcher JA, Robertson G, Shen R, Aburatani H, Robinson BW, Campbell P, Ladanyi M. Integrative Molecular Characterization of Malignant Pleural Mesothelioma. Cancer Discov. pii: CD-18-0804, 2018. (PMID: 30322867)
  6. Ohara Y, Chew SH, Misawa N, Wang S, Somiya D, Nakamura K, Kajiyama H, Kikkawa F, Tsuyuki Y, Jiang L, Yamashita K, Sekido Y, Lipson KE, Toyokuni S. Connective tissue growth factor-specific monoclonal antibody inhibits growth of malignant mesothelioma in an orthotopic mouse model. Oncotarget. 9:18494-18509, 2018. (PMID: 29719620)
  7. (2017)
  8. Tanaka K, Osada H, Murakami-Tonami Y, Horio Y, Hida T, Sekido Y: Statin suppresses Hippo pathway-inactivated malignant mesothelioma cells and blocks the YAP/CD44 growth stimulatory axis. Cancer Lett 385: 215-224, 2017. (PMID: 27773750)
  9. Kakumu T, Sato M, Goto D, Kato T, Yogo N, Hase T, Morise M, Fukui T, Yokoi K, Sekido Y, Girard L, Minna JD, Byers LA, Heymach JV, Coombes KR, Kondo M, Hasegawa Y: Identification of Proteasomal Catalytic Subunit PSMA6 as a Therapeutic Target for Lung Cancer. Cancer Sci 108(4):732-743, 2017. (PMID: 28165654)
  10. Fukushima K, Wang M, Naito Y, Uchihashi T, Kato Y, Mukai S, Yabuta N, Nojima H: GAK is phosphorylated by c-Src and translocated from the centrosome to chromatin at the end of telophase. Cell Cycle 31:1-13, 2017. (PMID: 28135906)
  11. Kato T, Sato T, Yokoi K, Sekido Y: E-cadherin expression is correlated with focal adhesion kinase inhibitor resistance in Merlin-negative malignant. Oncogene 36(39):5522-5531, 2017. (PMID: 28553954)
  12. Chew SH, Okazaki Y, Akatsuka S, Wang S, Jiang L, Ohara Y, Ito F, Saya H, Sekido Y, Toyokuni S: Rheostatic CD44 isoform expression and its association with oxidative stress in human malignant mesothelioma. Free Radic Biol Med 106:91-99, 2017. (PMID: 28185919)
  13. Kakumu T, Sato M, Goto D, Kato T, Yog, N, Hase T, Morise M, Fukui T, Yokoi K, Sekido Y, Girard L, Minna JD, Byers LA, Heymach JV, Coombes KR, Kondo M, Hasegawa Y: Identification of proteasomal catalytic subunit PSMA6 as a therapeutic target for lung cancer. Cancer Sci 108(4):732-743, 2017. (PMID: 28165654)
  14. Lin KC, Moroishi T, Meng Z, Jeong HS, Plouffe SW, Sekido Y, Han J, Park HW, Guan KL: Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation. Nat Cell Biol 19(8):996-1002,2017. (PMID: 28752853)
  15. Shishido Y, Tomoike F, Kimura Y, Kuwata K, Yano T, Fukui K, Fujikawa H, Sekido Y, Murakami-Tonami Y, Kameda T, Shuto S, Abe H: A Covalent G-site Inhibitor for Glutathione S-Transferase Pi (GSTP1-1). Chem Commun (Camb) 53(81):11138-11141,2017. (PMID: 28848941)
  16. Sato T, Higuchi Y, Shibagaki Y, Hattori S: Phosphoproteomic Analysis Identifies Signaling Pathways Regulated by Curcumin in Human Colon Cancer Cells. Anticancer Res 37(9):4789-4798, 2017. (PMID: 28870897)
  17. Shigeeda W, Shibazaki M, Yasuhira S, Kaneko Y, Masuda T, Tanita T, Sato T, Sekido Y, Maesawa C: Hyaluronic acid enhances cell migration and invasion via the YAP1/TAZ-RHAMM axis in malignant pleural mesothelioma. Oncotarget 8(55):93729-93740, 2017. (PMID: 29212185)
  18. (2016)
  19. Wang S, Jiang L, Han Y, Hwu Chew S, Ohara Y, Akatsuka S, Weng L, Kawaguchi K, Fukui T, Sekido Y, Yokoi K, Toyokuni S: Urokinase-type plasminogen activator receptor promotes proliferation and invasion with reduced cisplatin sensitivity in malignant mesothelioma. Oncotarget 7: 69565-69578, 2016. (PMID: 27602956)
  20. Ito T, Matsubara D, Tanaka I, Makiya K, Tanei ZI, Kumagai Y, Shiu SJ, Nakaoka HJ, Ishikawa S, Isagawa T, Morikawa T, Shinozaki-Ushiku A, Goto Y, Nakano T, Tsuchiya T, Tsubochi H, Komura D, Aburatani H, Dobashi Y, Nakajima J, Endo S, Fukayama M, Sekido Y, Niki T, Murakami, Y: Loss of YAP1 defines neuroendocrine differentiation of lung tumors. Cancer Sci 107: 1527-1538, 2016. (PMID: 27418196)
  21. Murakami-Tonami Y, Ikeda H, Yamagishi R, Inayoshi M, Inagaki S, Kishida S, Komata Y, Jan Koster, Takeuchi I, Kondo Y, Maeda T, Sekido Y, Murakami H, Kadomatsu K: SGO1 is involved in the DNA damage response in MYCN-amplified neuroblastoma cells. Sci Rep 19;6:31615, 2016. (PMID: 27539729)
  22. Yabuta N, Yoshida K, Mukai S, Kato Y, Torigata K, Nojima H: Large tumor suppressors 1 and 2 regulate Aurora-B through phosphorylation of INCENP to ensure completion of cytokinesis. Heliyon 20;2, 2016. (PMID: 27512725)
  23. Torigata K, Okuzaki D, Mukai S, Hatanaka A, Ohka F, Motooka D, Nakamura S, Ohkawa Y, Yabuta N, Kondo Y, Nojima H : LATS2 Positively Regulates Polycomb Repressive Complex. PLoS One 19:11, 2016. (PMID: 27434182)
  24. Mizuuchi H, Suda K, Murakami I, Sakai K, Sato K, Kobayashi Y, Shimoji M, Chiba M, Sesumi Y, Tomizawa K, Takemoto T, Sekido Y, Nishio K, Mitsudomi T: Oncogene swap as a novel mechanism of acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitor in lung cancer. Cancer Sci 107: 461-8, 2016. (PMID: 26845230)
  25. Hikasa H, Sekido Y, Suzuki A: Merlin/NF2-Lin28B-let-7 Is a Tumor-Suppressive Pathway that Is Cell-Density Dependent and Hippo Independent. Cell Rep 14: 2950-61, 2016. (PMID: 26997273)
  26. Nishio M, Sugimachi K, Goto H, Wang J, Morikawa T, Miyachi Y, Takano Y, Hikasa H, Itoh T, Suzuki SO, Kurihara H, Aishima S, Leask A, Sasaki T, Nakano T, Nishina H, Nishikawa Y, Sekido Y, Nakao K, Shin-Ya K, Mimori K, Suzuki A: Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice. Proc Natl Acad Sci U S A 113: E71-80, 2016. (PMID: 26699479)
  27. (2015)
  28. Tanaka K, Hida T, Oya Y, Oguri T, Yoshida T, Shimizu J, Horio Y, Hata A, Kaji R, Fujita S, Sekido Y, Kodaira T, Kokubo M, Katakami N, Yatabe Y: EGFR Mutation Impact on Definitive Concurrent Chemoradiation Therapy for Inoperable Stage III Adenocarcinoma. J Thorac Oncol 10: 1720-5, 2015. (PMID: 26743855)
  29. Hakiri S, Osada H, Ishiguro F, Murakami H, Murakami-Tonami Y, Yokoi K, Sekido Y: Functional differences between wild-type and mutant-type BRCA1-associated protein 1 tumor suppressor against malignant mesothelioma cells. Cancer Sci 106: 990-9, 2015. (PMID: 26011428)
  30. Tanahashi K, Natsume A, Ohka F, Motomura K, Alim A, Tanaka I, Senga T, Harada I, Fukuyama R, Sumiyoshi N, Sekido Y, Wakabayashi T: Activation of Yes-Associated Protein in Low-Grade Meningiomas Is Regulated by Merlin, Cell Density, and Extracellular Matrix Stiffness. J Neuropathol Exp Neurol 74: 704-9, 2015. (PMID: 26049897)
  31. Mizuuchi H, Suda K, Sato K, Tomida S, Fujita Y, Kobayashi Y, Maehara Y, Sekido Y, Nishio K, Mitsudomi T: Collateral Chemoresistance to Anti- Microtubule Agents in a Lung Cancer Cell Line with Acquired Resistance to Erlotinib. PLoS ONE 10: e0123901, 2015. (PMID: 25875914)
  32. Nakaguro M, Kiyonari S, Kishida S, Cao D, Murakami-Tonami Y, Ichikawa H, Takeuchi I, Nakamura S, Kadomatsu K: Nucleolar protein PES1 is a marker of neuroblastoma outcome and is associated with neuroblastoma differentiation. Cancer Sci 106: 237-43, 2015. (PMID: 25557119)
  33. Yamashita R, Sato M, Kakumu T, Hase T, Yogo N, Maruyama E, Sekido Y, Kondo M, Hasegawa Y: Growth inhibitory effects of miR-221 and miR-222 in non-small cell lung cancer cells. Cancer Med 4: 551-64, 2015. (PMID: 25641933)
  34. Gao W, Gu Y, Li Z, Cai H, Peng Q, Tu M, Kondo Y, Shinjo K, Zhu Y, Zhang J, Sekido Y, Han B, Qian Z, Miao Y: miR-615-5p is epigenetically inactivated and functions as a tumor suppressor in pancreatic ductal adenocarcinoma. Oncogene 34: 1629-40, 2014. (PMID: 24769899)
  35. Li Q, Wang W, Machino Y, Yamada T, Kita K, Oshima M, Sekido Y, Tsuchiya M, Suzuki Y, Nan-Ya K, Iida S, Nakamura K, Iwakiri S, Itoi K, Yano S: Therapeutic activity of glycoengineered anti-GM2 antibodies against malignant pleural mesothelioma. Cancer Sci 106: 102-7, 2015. (PMID: 25421609)
  36. Tanaka I, Osada H, Fujii M, Fukatsu A, Hida T, Horio Y, Kondo Y, Sato A, Hasegawa Y, Tsujimura T, Sekido Y: LIM-domain protein AJUBA suppresses malignant mesothelioma cell proliferation via Hippo signaling cascade. Oncogene 34:73-83, 2015. (PMID: 24336325)
  37. (2014)
  38. Suda K, Mizuuchi H, Murakami I, Uramoto H, Tanaka F, Sato K, Takemoto T, Iwasaki T, Sekido Y, Yatabe Y, Mitsudomi T: CRKL amplification is rare as a mechanism for acquired resistance to kinase inhibitors in lung cancers with epidermal growth factor receptor mutation. Lung Cancer 85: 147-51, 2014. (PMID: 24939008)
  39. Fernandez-Cuesta L, Plenker D, Osada H, Sun R, Menon R, Leenders F, Ortiz-Cuaran S, Peifer M, Bos M, DaBler J, Malchers F, Schottle J, Vogel W, Dahmen I, Koker M, Ullrich RT, Wright GM, Russell PA, Wainer Z, Solomon B, Brambilla E, Nagy-Mignotte H, Moro-Sibilot D, Brambilla CG, Lantuejoul S, Altmuller J, Becker C, Nurnberg P, Heuckmann JM, Stoelben E, Petersen I, Clement JH, Sanger J, Muscarella LA, la Torre A, Fazio VM, Lahortiga I, Perera T, Ogata S, Parade M, Brehmer D, Vingron M, Heukamp LC, Buettner R, Zander T, Wolf J, Perner S, Ansen S, Haas SA, Yatabe Y, Thomas RK: CD74-NRG1 fusions in lung adenocarcinoma. Cancer Discovery 4: 415-22, 2014. (PMID: 24469108)
  40. Murakami-Tonami Y, Kishida S, Takeuchi I, Katou Y, Maris JM, Ichikawa H, Kondo Y, Sekido Y, Shirahige K, Murakami H, Kadomatsu K: Inactivation of SMC2 shows a synergistic lethal response in MYCN-amplified neuroblastoma cells. Cell Cycle 13: 1115-31, 2014. (PMID: 24553121)
  41. Okamoto Y, Shinjo K, Shimizu Y, Sano T, Yamao K, Gao W, Fujii M, Osada H, Sekido Y, Murakami S, Tanaka Y, Joh T, Sato S, Takahashi S, Wakita T, Zhu J, Issa JP, Kondo Y: Hepatitis virus infection affects DNA methylation in mice with humanized livers. Gastroenterology 146: 562-72, 2014. (PMID: 24184133)
  42. Fukatsu A, Ishiguro F, Tanaka I, Kudo T, Nakagawa K, Shinjo K, Kondo Y, Fujii M, Hasegawa Y, Tomizawa K, Mitsudomi T, Osada H, Hata Y, Sekido Y: RASSF3 downregulation increases malignant phenotypes of non-small cell lung cancer. Lung Cancer 83: 23-9, 2014. (PMID: 24246507)
  43. Chew SH, Okazaki Y, Nagai H, Misawa N, Akatsuka S, Yamashita K, Jiang L, Yamashita Y, Noguchi M, Hosoda K, Sekido Y, Takahashi T, Toyokuni S: Cancer-promoting role of adipocytes in asbestos-induced mesothelial carcinogenesis through dysregulated adipocytokine production. Carcinogenesis 35: 164-72, 2014. (PMID: 23917077)
  44. (2013)
  45. Yamada T, Takeuchi S, Fujita N, Nakamura A, Wang W, Li Q, Oda M, Mitsudomi T, Yatabe Y, Sekido Y, Yoshida J, Higashiyama M, Noguchi M, Uehara H, Nishioka Y, Sone S, Yano S: Akt kinase-interacting protein1, a novel therapeutic target for lung cancer with EGFR-activating and gatekeeper mutations. Oncogene 32: 4427-35, 2013. (PMID: 23045273)
  46. Natsume A, Ito M, Katsushima K, Ohka F, Hatanaka A, Shinjo K, Sato S, Takahashi S, Ishikawa Y, Takeuchi I, Shimogawa H, Uesugi M, Okano H, Kim SU, Wakabayashi T, Issa JP, Sekido Y, Kondo Y: Chromatin regulator PRC2 is a key regulator of epigenetic plasticity in glioblastoma. Cancer Res 73: 4559-70, 2013. (PMID: 23720055)
  47. Sekido Y: Molecular pathogenesis of malignant mesothelioma. Carcinogenesis 34: 1413-9, 2013. (PMID: 23677068)
  48. Xue X, Gao W, Sun B, Xu Y, Han B, Wang F, Zhang Y, Sun J, Wei J, Lu Z, Zhu Y, Sato Y, Sekido Y, Miao Y, Kondo Y: Vasohibin 2 is transcriptionally activated and promotes angiogenesis in hepatocellular carcinoma. Oncogene 32: 1724-34, 2013. (PMID: 22614011)
  49. Nakagawa T, Takeuchi S, Yamada T, Ebi H, Sano T, Nanjo S, Ishikawa D, Sato M, Hasegawa Y, Sekido Y, Yano S: EGFR-TKI resistance due to BIM polymorphism can be circumvented by in combination with HDAC inhibition. Cancer Res 73: 2428-34, 2013. (PMID: 23382048)
  50. Abe S, Morita Y, Kato-Kaneko M, Hanibuchi M, Tsujimoto Y, Goto H, Kakiuchi S, Aono Y, Huang J, Sato S, Kishuku M, Taniguchi Y, Azuma M, Kawazoe K, Sekido Y, Yano S, Akiyama S, Sone S, Minakuchi K, Kato Y, Nishioka Y: A novel targeting therapy of malignant mesothelioma using anti-podoplanin antibody. J Immunol 190: 6239-40, 2013. (PMID: 23690472)
  51. Satoh M, Takemura Y, Hamada H, Sekido Y, Kubota S: EGCG induces human mesothelioma cell death by inducing reactive oxygen species and autophagy. Cancer Cell Int 13:19, 2013. (PMID: 23432995)
  52. Ishiguro F, Murakami H, Mizuno T, Fujii M, Kondo Y, Usami N, Taniguchi T, Yokoi K, Osada H, Sekido Y: Membranous expression of activated leukocyte cell adhesion molecule (ALCAM) contributes to poor prognosis and malignant phenotypes of non-small cell lung cancer. J Surg Research 179: 24-32, 2013. (PMID: 22985775)

【和文総説】

  1. 山本信之、中野孝司、関戸好孝ら.「EBMの手法による肺癌診療ガイドライン・悪性胸膜中皮腫・胸腺腫瘍を含む 2016年度版」 日本肺癌学会編 金原出版株式会社, 2016
  2. 関戸好孝.「石綿の曝露はヒト体内で何をおこすのか:ヒトにおける遺伝子変異」15-22 "石綿関連疾患の病理とそのリスクコミュニケーション"井内康輝 編 篠原出版新社 2015年
  3. 関戸好孝.「Hippo シグナルとがん」"発生・器官形成、がん悪性化に関わるHippoシグナル" 実験医学2015年11月号 vol.33 2934-9. 羊土社 
  4. 関戸好孝.「悪性中皮腫の遺伝子異常」(特別編集 豊國伸哉) 病理と臨床. 文光堂. 614-8. 2014.
  5. 関戸好孝.「悪性中皮腫とHippo pathway」"広がるHippo pathway 研究" 医学のあゆみ 2014年11月号 423-7 
  6. 関戸好孝.「悪性胸膜中皮腫の遺伝子異常・遺伝子治療」(中野孝司 編) 胸膜全書〜胸膜疾患のグローバルスタンダード〜. 医薬ジャーナル社. 277-85. 2013.
  7. 関戸好孝.「悪性胸膜中皮腫にみられる遺伝子異常」"胸膜全書"医薬ジャーナル2013年277-85.
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