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分子診断トランスレーショナルリサーチ分野

研究業績

【2018年】

  1. Shiels M, Kirk G, M. Drummond B, Dhillon D, Hanash S, Taguchi A, Engels E. HIV infection and Circulating Levels of Pro-Surfactant Protein B and Surfactant Protein D. J Infect Dis. 217(3):413-7、2018.
  2. Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Consortium for Early Detection of Lung Cancer, Guida F, Sun N, Bantis LE, Muller DC, Li P, Taguchi A, Dhillon D, Kundnani DL, Patel NJ, Yan Q, Byrnes G, Moons KGM, Tjonneland A, Panico S, Agnoli C, Vineis P, Palli D, Bueno-de-Mesquita B, Peeters PH, Agudo A, Huerta JM, Dorronsoro M, Barranco MR, Ardanaz E, Travis RC, Byrne KS, Boeing H, Steffen A, Kaaks R, Husing A, Trichopoulou A, Lagiou P, La Vecchia C, Severi G, Boutron-Ruault MC, Sandanger TM, Vainio EW, Nost TH, Tsilidis K, Riboli E, Grankvist K, Johansson M, Goodman GE, Feng Z, Brennan P, Johansson M, Hanash SM. Assessment of Lung Cancer Risk on the Basis of a Biomarker Panel of Circulating Proteins. JAMA Oncol. 2018 Jul 12:e182078. doi: 10.1001/jamaoncol.2018.2078.
  3. Fahrmann JF, Bantis LE, Capello M, Scelo G, Dennison JB, Patel N, Murage E, Vykoukal J, Kundnani DL, Foretova L, Fabianova E, Holcatova I, Janout V, Feng Z, Yip-Schneider M, Zhang J, Brand R, Taguchi A, Maitra A, Brennan P, Max Schmidt C, Hanash S. A Plasma-Derived Protein-Metabolite Multiplexed Panel for Early-Stage Pancreatic Cancer. J Natl Cancer Inst. 2018 Aug 18. doi: 10.1093/jnci/djy126.

【2017年】

  1. Fu R, Wang P, Taguchi A, Wong CH, Zhang Q, Gazdar A, Hanash S, Feng Z. A statistical method for detecting differentially expressed SNVs based on next-generation RNA-seq data. Biometrics. 73(1): 42-51, 2017.
  2. Çeliktaş M, Tanaka I, Tripathi S, Fahrmann J, Aguilar-Bonavides C, Villalobos P, Delgado O, Dhillon D, Dennison J, Ostrin E, Wang H, Behrens C, Do K, Gazdar A, Hanash S, Taguchi A. Role of CPS1 in cell growth, metabolism, and prognosis in LKB1-inactivated lung adenocarcinoma. J Natl Cancer Inst. 109(3): 1-9, 2017.
  3. Capello M, Bantis L, Scelo G, Zhao Y, Li P, Dhillon D, Patel N, Kundnani D, Wang H, Abbruzzese J, Maitra A, Tempero M, Brand R, Foretova L, Fabianova E, Holcatova I, Janout V, Firpo M, Mulvihill S, Katz M, Brennan P, Feng Z, Taguchi A, Hanash S. Sequential Validation of Blood-Based Protein Biomarker Candidates for Early-Stage Pancreatic Cancer. J Natl Cancer Inst. 109(4): djw266, 2017.
  4. Tripathi S, Fahrmann J, Celiktas M, Aguilar M, Marini K, Jolly M, Katayama H, Wang H, Murage E, Dennison J, Watkins D, Levine H, Ostrin J, Taguchi A, Hanash S. MCAM Mediates Chemoresistance in Small-Cell Lung Cancer via the PI3K/AKT/SOX2 Signaling Pathway. Cancer Res. 77(16): 4414-25, 2017.
  5. Vykoukal J, Sun N, Aguilar-Bonavides C, Katayama H, Tanaka I, Fahrmann JF, Capello M, Fujimoto J, Aguilar M, Wistuba II, Taguchi A, Ostrin EJ, Hanash SM. Plasma-derived extracellular vesicle proteins as a source of biomarkers for lung adenocarcinoma. Oncotarget. 8(56):95466-80, 2017.

【2016年】

  1. Ruhaak R, Stroble C, Dai J, Barnett M, Taguchi A, Goodman G, Miyamoto S, Gandara D, Feng Z, Lebrilla C, Hanash S. Serum glycans as risk markers for non-small cell lung cancer. Cancer Prev Res. 9(4): 317-23, 2016.
  2. Redis RS, Vela LE, Lu W, Ferreira de Oliveira J, Ivan C, Rodriguez-Aguayo C, Adamoski D, Pasculli B, Taguchi A, Chen Y, Fernandez AF, Valledor L, Van Roosbroeck K, Chang S, Shah M, Kinnebrew G, Han L, Atlasi Y, Cheung LH, Huang GY, Monroig P, Ramirez MS, Catela Ivkovic T, Van L, Ling H, Gafa R, Kapitanovic S, Lanza G, Bankson JA, Huang P, Lai SY, Bast RC, Rosenblum MG, Radovich M, Ivan M, Bartholomeusz G, Liang H, Fraga MF, Widger WR, Hanash S, Berindan-Neagoe I, Lopez-Berestein G, Ambrosio ALB, Gomes Dias SM, Calin GA. Allele-Specific Reprogramming of Cancer Metabolism by the Long Non-coding RNA CCAT2. Mol Cell. 2016 Feb 18;61(4):520-534.
  3. Tripathi S, Peters H, Taguchi A, Katayama H, Wang H, Momin A, Jolly M, Celiktas M, Rodriguez J, Liu H, Behrens C, Wistuba I, Ben-Jacob E, Levine H*, Molldrem J, Hanash S, Ostrin E. Immunoproteasome deficiency is a feature of non-small cell lung cancer with a mesenchymal phenotype and is associated with a poor outcome. Proc Natl Acad Sci U S A. 2016, 113(11): E1555-64, 2016.

【2015年までの主要な業績】

  1. Wikoff WR, Hanash S, DeFelice B, Miyamoto S, Barnett M, Zhao Y, Goodman G, Feng Z, Gandara D, Fiehn O, Taguchi A. Diacetylspermine Is a Novel Prediagnostic Serum Biomarker for Non-Small-Cell Lung Cancer and Has Additive Performance With Pro-Surfactant Protein B. J Clin Oncol. 33(33): 3880-6, 2015.
  2. Capello M, Lee M, Wang H, Babel I, Katz M, Fleming J, Maitra A, Wang H, Tian W, Taguchi A, Hanash S. Identification of Carboxylesterase 2 as a Determinant of Response to Irinotecan and to Neoadjuvant FOLFIRINOX Therapy in Pancreatic Ductal Adenocarcinoma. J Natl Cancer Inst. 107(8): djv132, 2015.
  3. Taguchi A, Taylor AD, Rodriguez J, Çeliktaş M, Liu H, Ma X, Zhang Q, Wong CH, Chin A, Girard L, Behrens C, Lam WL, Lam S, Minna JD, Wistuba II, Gazdar AF, and Hanash SM. A search for novel cancer/testis antigens in lung cancer identifies VCX/Y genes, expanding the repertoire of potential immunotherapeutic targets. Cancer Res. 74(17): 4694-705, 2014.
  4. Sin DD, Tammemagi CM, Lam S, Barnett MJ, Duan X, Tam A, Auman H, Feng Z, Goodman GE, Hanash SM, and Taguchi A. Pro-Surfactant Protein B as a Biomarker for Lung Cancer Prediction. J Clin Oncol. 31(36): 4536-43, 2013.
  5. Taguchi A, Hanash SM. Unleashing the Power of Proteomics to Develop Blood-Based Cancer Markers. Clin Chem. 59(1):119-26, 2013.
  6. Taguchi A, Politi K, Pitteri SJ, Lockwood WW, Faca VM, Kelly-Spratt K, Wong CH, Zhang Q, Chin A, Park KS, Goodman G, Gazdar AF, Sage J, Dinulescu DM, Kucherlapati R, Depinho RA, Kemp CJ, Varmus HE, Hanash SM. Lung cancer signatures in plasma based on proteome profiling of mouse tumor models. Cancer Cell. 20(3):289-99, 2011.
  7. Hanash S, Taguchi A. The grand challenge to decipher the cancer proteome. Nat Rev Cancer. 10(9):652-60, 2010
  8. Taguchi A, Yanagisawa K, Tanaka M, Cao K, Matsuyama Y, Goto H, Takahashi T. Identification of Hypoxia-Inducible Factor-1a as a novel target for mir-17-92 microRNA cluster. Cancer Res. 68(14):5540-5, 2008.
  9. Ohmiya N, Taguchi A, Mabuchi N, Itoh A, Hirooka Y, Niwa Y, Goto H. MDM2 promoter polymorphism is associated with both an increased susceptibility to gastric carcinoma and poor prognosis. J Clin Oncol. 24(27):4434-40, 2006.
  10. Taguchi A, Ohmiya N, Shirai K, Mabuchi N, Itoh A, Hirooka Y, Niwa Y, Goto H. Interleukin-8 promoter polymorphism increases the risk of atrophic gastritis and gastric cancer in Japan. Cancer Epidemiol Biomarkers Prev. 14(11 Pt 1):2487-93, 2005.

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